Texas Political Lobbyist News: Texas State Agencies and Interim Hearings 2012
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The University of Texas System July 9, 2012 – 12:00 PM Town Lake Conference Room 5.318A, North Office Bldg A (NOA), 101 East 27th Street, Austin
Institutional Animal Care and Use Committee (IACUC) Complete agenda (single space): 1. Call to Order. 2. Reminder of Conflict of Interest Policy. 3. Report on Protocols Approved by Designated Member Review (DMR) from June 11, 2012 through July 8, 2012. A. 10062401: Thermoradiotherapy of Tumors Using Gold Nanoparticles and Kilovolt Radiation Therapy B. 10070101: Engineering and Evaluation of Human L-Methionase for Cancer Therapy C. 11062702: Small animal models of invasive aspergillosis: Task Order A05 D. 11062703: Small animal models of invasive fungi: Task Order A13 E. 11062704: Pharmacokinetics and in vivo efficacy of the investigational echinocandin ASP9726 against invasive pulmonary aspergillosis F. 12052201: Combining Nanoparticles with Radiation Therapy G. 12060401: Mechanisms of in-vivo remodeling in tissue engineered heart valves H. AUP-2009-00036: Mitochondrial Bioenergetics and Carcinogenesis I. AUP-2009-00080: Eyelid conditioning in the rabbit J. AUP-2009-00128: Group II intron gene targeting in Xenopus K. AUP-2010-00063: Transcriptional and behavioral regulation by estradiol during aging L. AUP-2010-00071: Studies in Texaphyrin Platinum Analogues: Maximum Tolerated Dose, Pharmacokinetic/Pharmacodynamic, and Efficacy M. AUP-2010-00076: Isolation of Neural Progenitors from Embryonic Mice Hippocampus, Forebrain, and Midbrain N. AUP-2010-00084: Thymocyte: stromal interactions during normal and lymphomagenic T cell deveopment O. AUP-2010-00088: Posttranscriptional Regulation, a Novel Mechanism for Ion Channel Regulation and Dendritic Excitability P. AUP-2010-00096: Evaluation of glucose monitoring and insulin delivery in minipigs Q. AUP-2010-00116: Analyzing the role of adult hippocampal neurogenesis in cognitive processes R. AUP-2010-00122: Evaluation of glucose monitoring and insulin pumping in chickens S. AUP-2010-00140: Activity-dependent circuit mapping T. AUP-2010-00142: Neurophysiology of the hippocampus and its inputs in freely behaving rats U. AUP-2010-00160: Calcium signaling in the reward circuit and drug addiction V. AUP-2010-00164: Anti-adhesive implants of hyaluronan and alginate in peritoneal cavity W. AUP-2010-00203: Studies in Molecular Therapy X. AUP-2011-00069: Neurochemical mechanisms of ethanol self-administration Y. AUP-2011-00073: Analysis of cerebellar mechanisms of learning using in vivo recordings Z. AUP-2011-00088: Reversible inactivation of hippocampal neurons AA. AUP-2011-00090: Pharmacokinetics of Caffeic Acid Phenethyl Amide (CAPA) in Male Sprague-Dawley Rats BB. AUP-2011-00100: Role of Bop in cardiac function CC. AUP-2011-00102: Evaluation of Reproductive, behavioral and population effects of moderate hypoxia DD. AUP-2011-00103: Evolution of resistance to pain-inducing neurotoxins: the bark scorpion-grasshopper mouse system EE. AUP-2011-00105: Collaborative Research: Multimodal communication, mate choice and predation risk FF. AUP-2011-00108: Epigenome Interactions in Complex Neurogenetic Disorders GG. AUP-2011-00136: Neuronal Mechanisms of Working Memory in Prefrontal Cortex HH. AUP-2011-00155: Sentinel Protocol ARC II. AUP-2012-00055: Ultrastructure of brain synapses JJ. AUP-2012-00061: Genomic tagging of gut microflora for the quantification of horizontal gene transfer KK. AUP-2012-00072: Novel molecular and cellular approaches for alcoholism medication development 4. Discussion and appropriate action regarding minutes of previous meeting(s). A. June 11, 2012 Full Committee Review (FCR). 5. Announcements A. Reminder: Upcoming IACUC Training Opportunity 6. Discussion and appropriate action regarding The University of Texas at Austin’s Office of Laboratory Animal Welfare (OLAW) Animal Welfare Assurance renewal. 7. Discussion and appropriate action regarding several alleged reports of non-compliance and recent correspondence with OLAW. 8. Discussion and appropriate action regarding proposed revisions to the guidance document entitled Guidelines for the Environmental Enrichment of Laboratory Rodents’ to be issued by the Committee. 9. Report from the HealthPoint Occupational Health Program (OHP) and discussion and appropriate action regarding quarterly enrollment and laboratory incidents as they relate to the University’s Animal Care and Use Program. 10. Continuing Education A. Stave GM & Darcey DJ. 2012. Prevention of Laboratory Animal Allergy in the United States: A National Survey. Journal of Occupational and Environmental Medicine 54(5): 558-563. B. Cardon AD, Bailey MR, & Bennet BT. 2012. The Animal Welfare Act: From Enactment to Enforcement. Journal of the American Association for Laboratory Animal Science 51(3): 301-305. 11. Animal Resources Center (ARC) report on the population, active protocols and caring concern of the animals as well as the health status of the colonies. A. Attending Veterinarian’s Report B. Clinical Veterinarian’s Report 12. Discussion and appropriate action regarding review of protocols (new, annual renewal, and/or revision). A. AUP-2009-00121: Liposomal adjuvant for vaccine development B. AUP-2012-00011: Optogenetic control of neural circuits in vivo: Assessing hippocampal dopamine efflux C. AUP-2012-00056: Ultrastructural basis of hippocampal neurophysiology D. AUP-2012-00071: Transgenerational epigenetic effects of PCBs on neuroendocrine systems E. AUP-2012-00075: Use of the metastatic 4T1.2 and p53 knockout (KO) mouse mammary tumor cell lines to develop and identify anti-cancer targets F. AUP-2012-00076: Differential Fos expression in GABA-producing neurons in the mPOA following either exposure to an estrous female or copulation in both sexually experienced and naive male rats G. AUP-2012-00078: Antigen-Induced Plasmablast Response in the Rat H. AUP-2012-00081: Molecular Mechanisms in vertebrate midbrain development I. AUP-2012-00084: Pharmacokinetic Studies of Delivery Methods for Engineered Antibodies and Protein Drugs J. AUP-2012-00085: Neural basis of perception, cognition, and action K. AUP-2012-00086: Brain mechanisms of fear memory encoding and attenuation L. AUP-2012-00087: INS bootcamp Molecular and Behavioral module M. AUP-2012-00088: Pharmacokinetics and Maximum Tolerated Dose Studies of Small Molecules 12. Minority Report: An opportunity for any member to express any minority views of any of the agenda items. 13. The next scheduled meeting is Monday, August 13, 2012 at noon in NOA 5.318A. 14. Adjourn Meeting Accessibility: Meetings of the Institutional Animal Care and Use Committee are open to the public except for any posted executive session held in compliance with the Texas Open Meetings Act. Additional Information Contact: 512/463-5561